Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity
Edward Pajarillo, James Johnson, Asha Rizor, Ivan Nyarko‐Danquah, Getinet M. Adinew, Julia Bornhorst, Michael Stiboller, Tania Schwerdtle, Deok-Soo Son, Michael Aschner, Eun-Sook Lee
Abstract
, at least in part, by reducing astrocytic GLAST/GLT-1. Thus, YY1 might be a potential target for treatment of Mn toxicity and other neurological disorders associated with dysregulation of GLAST/GLT-1.
Topics & Concepts
Substantia nigraNeurotoxicityAstrocyteDopaminergicTyrosine hydroxylaseStriatumMolecular biologyChemistryBiologyEndocrinologyDopamineToxicityCentral nervous systemOrganic chemistryHeavy Metal Exposure and ToxicityTrace Elements in HealthNuclear Receptors and Signaling