Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury
Jing-Yuan Cao, Bin Wang, Tao‐Tao Tang, Yi Wen, Zuo‐Lin Li, Songtao Feng, Min Wu, Dan Liu, Di Yin, Kun-Ling Ma, Ri‐Ning Tang, Qiuli Wu, Hui-Yao Lan, Lin‐Li Lv, Bi‐Cheng Liu
Abstract
MSC-exos exhibit preferential tropism to injured kidney and localize to proximal tubules in ischemic AKI. We demonstrate that MSC-exos ameliorate ischemic AKI and promote tubular repair by targeting the cell cycle arrest and apoptosis of TECs through miR-125b-5p/p53 pathway. This study provides a novel insight into the role of MSC-exos in renal tubule repair and highlights the potential of MSC-exos as a promising therapeutic strategy for AKI.
Topics & Concepts
Mesenchymal stem cellMicrovesiclesAcute kidney injuryMedicineCancer researchRenal stem cellStem cellKidneyExosomePathologyCell injuryCell biologymicroRNAChemistryBiologyInternal medicineApoptosisProgenitor cellBiochemistryGeneExtracellular vesicles in diseaseAcute Kidney Injury ResearchMuscle and Compartmental Disorders