Alkali halides as nucleophilic reagent sources for N-directed palladium-catalysed<i>ortho</i>-C–H halogenation of<i>s</i>-tetrazines and other heteroaromatics
Ahmad Daher, Oumaima Abidi, Jean‐Cyrille Hierso, Julien Roger
Abstract
A general palladium-catalysed selective C–H halogenation reaction is reported, which was successfully achieved for a large variety of functionalized aromatic rings incorporating diverse N-directing groups.
Topics & Concepts
HalogenationHalideChemistryPalladiumNucleophileReagentAlkali metalMedicinal chemistryOrganic chemistryCatalysisCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsClick Chemistry and Applications