Red-light-sensitive BODIPY photoprotecting groups for amines and their biological application in controlling heart rhythm
Kaja Sitkowska, Martijn F. Hoes, Michael M. Lerch, Lucien N. Lameijer, Peter van der Meer, Wiktor Szymański, Ben L. Feringa
Abstract
Control of biological function by the use of photoremovable protecting groups (PPGs) is a gateway towards many new medical developments. Herein, we report the synthesis and application of efficient and biocompatible BODIPY-based photoprotecting groups for amines, which are cleavable with red light in the phototherapeutic window region (λ > 650 nm). We use the most promising PPG for the protection of dopamine and apply it to control the beating frequency of human cardiomyocytes.
Topics & Concepts
BODIPYAmine gas treatingHeart RhythmRed lightChemistryHeart beatRhythmPhotochemistryCombinatorial chemistryBiophysicsOrganic chemistryMedicineFluorescenceCardiologyInternal medicineBiologyOpticsPhysicsBotanyPhotochromic and Fluorescence ChemistryPhotoreceptor and optogenetics researchLuminescence and Fluorescent Materials