Secondary loss of <i>miR-3607</i> reduced cortical progenitor amplification during rodent evolution
Kaviya Chinnappa, Adrián Cárdenas, Anna Prieto‐Colomina, Ana Villalba, Ángel Márquez-Galera, Rafael Soler, Yuki Nomura, Esther Llorens, Ugo Tomasello, José P. López‐Atalaya, Vı́ctor Borrell
Abstract
in ferret reduced RGC proliferation, while overexpression in human cerebral organoids promoted VZ expansion. Our results identify a gene selected for secondary loss during mammalian evolution to limit RGC amplification and, potentially, cortex size in rodents.
Topics & Concepts
RodentProgenitorProgenitor cellBiologyCell biologyStem cellPaleontologyRNA Research and SplicingMicroRNA in disease regulationGenetics, Aging, and Longevity in Model Organisms