The effect of acute and 14-day exogenous ketone supplementation on glycemic control in adults with type 2 diabetes: two randomized controlled trials
Kaja Falkenhain, Bárbara Fonseca de Oliveira, Hashim Islam, Helena Neudorf, Haoning Howard Cen, James D. Johnson, Kenneth Madden, Joel Singer, Jeremy J. Walsh, Jonathan P. Little
Abstract
Exogenous ketone supplements can acutely lower blood glucose, suggesting therapeutic potential in individuals with impaired glucose metabolism. However, the effect of exogenous ketones on glucose metabolism in adults with type 2 diabetes has not been investigated in a controlled setting. In adults with type 2 diabetes, ketone monoester ingestion did not lower blood glucose acutely in a fasted state and did not improve glycemic control across thrice daily premeal ingestion across 14 days.
Topics & Concepts
Ketone bodiesGlycemicInternal medicineIngestionEndocrinologyMedicineFructosamineDiabetes mellitusType 2 diabetesCrossover studyPlaceboRandomized controlled trialInsulinMetabolismAlternative medicinePathologyDiet and metabolism studiesDiet, Metabolism, and DiseaseMetabolism, Diabetes, and Cancer