Successful use of dupilumab in recalcitrant pediatric atopic dermatitis-like graft-versus-host disease: A case series
Lina Belmesk, Afshin Hatami, Julie Powell, Victor Kokta, Jérôme Coulombe
Abstract
Graft-versus-host disease (GvHD) is one of the most severe complications of allogenic hematopoietic stem cell transplantation (HSCT). Although GvHD often presents as a multiorgan disease, the first and most common clinical manifestations are cutaneous. While the number of indications for allogenic HSCT is expanding, dermatologists are challenged with various forms of cutaneous GvHD. Atopic dermatitis-like (AD-like) GvHD has been increasingly recognized by dermatologists over the last decade.
Topics & Concepts
MedicineDupilumabAtopic dermatitisGraft-versus-host diseaseHematopoietic stem cell transplantationDermatologyDiseaseTacrolimusImmunologyTransplantationPathologySurgeryHematopoietic Stem Cell TransplantationT-cell and B-cell ImmunologyDermatology and Skin Diseases