Nucleophilic strategies to construct –CF<sub>2</sub>– linkages using borazine-CF<sub>2</sub>Ar reagents
Michael M. Wade Wolfe, Shuo Guo, Lucy S. Yu, Trenton R. Vogel, Joseph W. Tucker, Nathaniel K. Szymczak
Abstract
Using nucleophilic, boron-based –CF 2 Ar reagents, we demonstrate three methods to form C–C F bonds: (1) nucleophilic aromatic substitution, (2) palladium catalyzed cross-coupling, and (3) nucleophilic substitution.
Topics & Concepts
SN2 reactionNucleophileReagentChemistryNucleophilic aromatic substitutionCatalysisNucleophilic substitutionDimerMoleculeCombinatorial chemistryLewis acids and basesComputational chemistryOrganic chemistryFluorine in Organic ChemistryOrganoboron and organosilicon chemistryCyclopropane Reaction Mechanisms