Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation
Luís F. Ribeiro, Tatiana Catarino, M. Carvalho, Luísa Cortes, Sandra D. Santos, Patricio Opazo, Lyn Rosenbrier Ribeiro, Bárbara Oliveiros, Daniel Choquet, José A. Esteban, João Peça, Ana Luı́sa Carvalho
Abstract
Reducing the ligand-independent activity of GHS-R1a increased the surface diffusion of AMPA receptors and impaired AMPA receptor-dependent synaptic delivery induced by chemical long-term potentiation. Accordingly, we found that blocking this GHS-R1a activity impaired spatial and recognition memory in mice. These observations support a role for the ligand-independent activity of GHS-R1a in regulating AMPA receptor trafficking under basal conditions and in the context of synaptic plasticity that underlies learning.
Topics & Concepts
GhrelinAMPA receptorReceptorLigand (biochemistry)Cell biologyChemistryBlocking (statistics)NeuroscienceBiologyBiochemistryNMDA receptorComputer scienceComputer networkRegulation of Appetite and ObesityBiochemical Analysis and Sensing Techniquesmelanin and skin pigmentation