Isoginkgetin, a potential CDK6 inhibitor, suppresses <i>SLC2A1/GLUT1</i> enhancer activity to induce AMPK-ULK1-mediated cytotoxic autophagy in hepatocellular carcinoma
Jie Yao, Shuming Tang, Chenyan Shi, Yunzhi Lin, Lanlan Ge, Qinghua Chen, Baoru Ou, Dongyu Liu, Yuyang Miao, Qiujie Xie, Xudong Tang, Fei Jia, Guangyi Yang, Jun Tian, Xiaobin Zeng
Abstract
, resulting in decreased glucose levels and inducing the AMPK-ULK1 pathway.
Topics & Concepts
GLUT1AutophagyAMPKCyclin-dependent kinase 6Cancer researchBiologyGlucose transporterMG132ChemistryCell biologyApoptosisEndocrinologyBiochemistryKinaseProtein kinase ACyclin D1Cell cycleInsulinProteasome inhibitorAutophagy in Disease and TherapyEpigenetics and DNA MethylationMetabolism, Diabetes, and Cancer