Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade
Joy A. Pai, Matthew D. Hellmann, Jennifer L. Sauter, Marissa S. Mattar, Hira Rizvi, Hyung Jun Woo, Nisargbhai Shah, Evelyn M. Nguyen, Fathema Uddin, Àlvaro Quintanal-Villalonga, Joseph M. Chan, Parvathy Manoj, Viola Allaj, Marina K. Baine, Umesh Bhanot, Mala Jain, Irina Linkov, Fanli Meng, David Alan Brown, Jamie E. Chaft, Andrew J. Plodkowski, Mathieu Gigoux, Helen Won, Triparna Sen, Daniel K. Wells, Mark T.A. Donoghue, Elisa de Stanchina, Jedd D. Wolchok, Brian Houck‐Loomis, Taha Merghoub, Charles M. Rudin, Andrew Chow, Ansuman T. Satpathy
Topics & Concepts
BiologyBlockadeImmune checkpointImmune systemLineage (genetic)Progenitor cellPersistence (discontinuity)Cell biologySomatic evolution in cancerCancer researchImmunologyImmunotherapyStem cellGeneticsGeneReceptorGeotechnical engineeringEngineeringCAR-T cell therapy researchCancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses