Elevated MicroRNA 183 Impairs Trophoblast Migration and Invasiveness by Downregulating FOXP1 Expression and Elevating GNG7 Expression during Preeclampsia
Weisi Lai, Ling Yu
Abstract
studies to explore effects of FOXP1 in the PE model. The results revealed suppressed expression of FOXP1 and significant elevations in miR-183 and GNG7 expression in placental tissues of PE patients. FOXP1 was observed to promote proliferation, invasion, and angiogenesis in human chorionic trophoblastic cells. miR-183 resulted in depletion of FOXP1 expression, while FOXP1 was capable of restraining GNG7 expression and promoting the mTOR pathway. The findings confirmed the effects of FOXP1 on PE. In conclusion, miR-183 exhibits an inhibitory role in PE through suppression of FOXP1 and upregulation of GNG7.
Topics & Concepts
BiologyTrophoblastmicroRNAPreeclampsiaDownregulation and upregulationAngiogenesisAndrologyCancer researchEndocrinologyPlacentaFetusMedicinePregnancyGeneticsGenePregnancy and preeclampsia studiesMicroRNA in disease regulationReproductive System and Pregnancy