Copper‐Catalyzed Enantioselective Trifluoromethoxylation of Propargyl Sulfonates
Yangdong Hou, Zhang Zhang, Xinyu Sun, Zheng Yang, Yu‐Xin Luan, Pingping Tang
Abstract
Abstract Due to the strong electron‐withdrawing nature and high lipophilicity of trifluoromethoxy group (OCF 3 ), methods for introducing OCF 3 into organic molecules are in high demand. However, the research area of direct enantioselective trifluoromethoxylation is still in the embryonic stage, with limited enantioselectivity and/or reaction types. Here, we describe the first copper‐catalyzed enantioselective trifluoromethoxylation of propargyl sulfonates using trifluoromethyl arylsulfonate (TFMS) as the trifluoromethoxy source in up to 96 % ee.
Topics & Concepts
Enantioselective synthesisPropargylTrifluoromethylLipophilicityCatalysisChemistryCopperOrganic chemistryCombinatorial chemistryAlkylFluorine in Organic ChemistryCyclopropane Reaction Mechanisms