Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of imidazo-heteroarenes
José S. S. Neto, Renata A. Balaguez, Marcelo S. Franco, Victor C. de Sá Machado, Sumbal Saba, Jamal Rafique, Fábio Z. Galetto, Antônio L. Braga
Abstract
Herein, we describe an efficient, rapid and benign protocol for the direct C(sp<sup>2</sup>)–H bond halogenation (Cl, Br, I) of 2-arylimidazo[1,2-<italic>a</italic>]pyridines using trihaloisocyanuric acids in ethanol.
Topics & Concepts
HalogenationRegioselectivityChemistryEthanolEnvironmentally friendlyOrganic chemistryMedicinal chemistryCombinatorial chemistryCatalysisBiologyEcologyCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsVanadium and Halogenation Chemistry