Nocturnal Hypoxemia and High Circulating TNF-α Levels in Chronic Thromboembolic Pulmonary Hypertension
Akira Naito, Seiichiro Sakao, Jiro Terada, Shunichiro Iwasawa, Takayuki Jujo, Rika Suda, Hajime Kasai, Ayumi Sekine, Rintaro Nishimura, Toshihiko Sugiura, Ayako Shigeta, Nobuhiro Tanabe, Koichiro Tatsumi
Abstract
Objective Chronic thromboembolic pulmonary hypertension (CTEPH) is a form of pulmonary hypertension caused by persistent thromboemboli of the pulmonary arteries, and one of its etiological factors may be inflammation. Sleep disordered breathing (SDB) is reportedly an important complication of pulmonary hypertension. However, the association between SDB and inflammation in CTEPH has been undefined. This prospective observational study analyzed the association between the severity of SDB, pulmonary hemodynamic parameters and the systemic inflammation level in patients with CTEPH.