Down-regulation of Beclin1 promotes direct cardiac reprogramming
Li Wang, Hong Ma, Peisen Huang, Yifang Xie, David Near, Haofei Wang, Jun Xu, Yuchen Yang, Yangxi Xu, Tiffany A. Garbutt, Yang Zhou, Ziqing Liu, Chaoying Yin, Michael Bressan, Joan M. Taylor, Jiandong Liu, Qian Li
Abstract
depletion in cardiac reprogramming. Collectively, our study revealed an inductive role of Atg5-dependent autophagy as well as a previously unrecognized autophagy-independent inhibitory function of Becn1 in iCM reprogramming.
Topics & Concepts
ReprogrammingAutophagyWnt signaling pathwayCell biologySignal transductionBiologyChemistryCancer researchGeneticsCellApoptosisAutophagy in Disease and TherapyAdenosine and Purinergic SignalingSignaling Pathways in Disease