Tetrabutylammonium Bromide (TBAB) Catalyzed Synthesis of Bioactive Heterocycles
Bimal Krishna Banik, Bubun Banerjee, Gurpreet Kaur, Shivam Saroch, Rajat Kumar
Abstract
During the last two decades, tetrabutylammonium bromide (TBAB) has gained significant attention as an efficient metal-free homogeneous phase-transfer catalyst. A catalytic amount of TBAB is sufficient to catalyze various alkylation, oxidation, reduction, and esterification processes. It is also employed as an efficient co-catalyst for numerous coupling reactions. It has also acted as an efficient zwitterionic solvent in many organic transformations under molten conditions. In this review, we have summarized the recent developments on TBAB-catalyzed protocols for the efficient synthesis of various biologically promising heterocyclic scaffolds.
Topics & Concepts
CatalysisAlkylationHomogeneousChemistryBromideCombinatorial chemistryPhase (matter)SolventOrganic synthesisOrganic chemistryBenzyl bromideThermodynamicsPhysicsQuinazolinone synthesis and applicationsMulticomponent Synthesis of HeterocyclesMicrowave-Assisted Synthesis and Applications