1,2,4-Triazolo[4,3-<i>c</i>]quinazolines: a bioisosterism-guided approach towards the development of novel PCAF inhibitors with potential anticancer activity
Mohamed H. El‐Shershaby, Adel Ghiaty, Ashraf H. Bayoumi, Hany E. A. Ahmed, Mona S. El‐Zoghbi, Khaled El‐Adl, Hamada S. Abulkhair
Abstract
Targeting PCAF with small inhibitor molecules has emerged as a potential therapeutic strategy for the treatment of cancer.
Topics & Concepts
ChemistryPCAFCombinatorial chemistryStereochemistryBiochemistryDNAHistoneQuinazolinone synthesis and applicationsSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activity