Highly diastereoselective cascade dearomatization of 3-(2-isocyanoethyl)indoles with nitrile imines: a facile access to unexpected polycyclic indolines
Xiaohu Zhao, Yuqiao Zhou, Baolin Li, Guangxi Du, Zhipeng Yu
Abstract
A novel cascade annulation between 2-isocyanoethylindoles and hydrazonyl chlorides has been realized to assemble a variety of unexpected polycyclic indoline derivatives with excellent diastereoselectivities under simple reaction conditions.
Topics & Concepts
ChemistryNitrileCascadeCombinatorial chemistryOrganic chemistryChromatographyCatalytic C–H Functionalization MethodsChemical Synthesis and AnalysisSynthesis and Catalytic Reactions