PD-L1 <sup>+</sup> neutrophils contribute to injury-induced infection susceptibility
Ajitha Thanabalasuriar, Abby J. Chiang, Christopher Morehouse, Margarita Camara, Shonda Hawkins, Ashley Keller, Adem C. Koksal, Carolina Caceres, Aaron A. Berlin, Nicholas Holoweckyj, Virginia Takahashi, Lily Cheng, Melissa de los Reyes, Mark Pelletier, Andriani C. Patera, Bret R. Sellman, Sonja Hess, Marcello Marelli, Chelsea C. Boo, Taylor S. Cohen, Antonio DiGiandomenico
Abstract
neutrophil accumulation in the lung. Systemic treatment of injured animals with an anti-PD-L1 antibody prevented neutrophil accumulation in the lung and reduced susceptibility to infection but augmented skin healing, resulting in increased epidermal growth. This work provides evidence that injury promotes changes to neutrophils that are important for wound healing but contribute to infection susceptibility.