The Landscape of Human Cancer Proteins Targeted by SARS-CoV-2
Beril Tutuncuoglu, Merve Çakır, Jyoti Batra, Mehdi Bouhaddou, Manon Eckhardt, David E. Gordon, Nevan J. Krogan
Abstract
The mapping of SARS-CoV-2 human protein-protein interactions by Gordon and colleagues revealed druggable targets that are hijacked by the virus. Here, we highlight several oncogenic pathways identified at the host-virus interface of SARS-CoV-2 to enable cancer biologists to apply their knowledge for rapid drug repurposing to treat COVID-19, and help inform the response to potential long-term complications of the disease.
Topics & Concepts
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)CancerCoronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakSars virusComputational biologyVirologyBiologyMedicineGeneticsDiseaseInfectious disease (medical specialty)OutbreakPathologyCancer Research and TreatmentsPARP inhibition in cancer therapyCancer Immunotherapy and Biomarkers