Combination of talazoparib and olaparib enhanced the curcumin-mediated apoptosis in oral cancer cells by PARP-1 trapping
Subhajit Chatterjee, Ajit Kumar Dhal, Subarno Paul, Saptarshi Sinha, Biswajit Das, Somya Ranjan Dash, Chanakya Nath Kundu
Topics & Concepts
OlaparibPoly ADP ribose polymeraseApoptosisCancer researchDNA damagePARP inhibitorPARP1CurcuminProgrammed cell deathDNA repairChemistryCancer cellCancerSynthetic lethalityBiologyCell biologyPolymeraseDNABiochemistryGeneticsPARP inhibition in cancer therapySirtuins and Resveratrol in MedicineCell death mechanisms and regulation