Recent advances in carboxyl-directed dimerizations and cascade annulations <i>via</i> C–H activations

Abstract

decarboxylation, which allows it to serve as a unique traceless directing group in C-H functionalization. These characteristics make carboxyl a promising directing group, which is superior to nitrogen-containing compounds with strong coordination ability to a certain extent. This feature article reviews the applications of carboxyl as a classical directing group and a unique traceless-directing group in cascade annulation reactions to access diverse carbocycles and heterocycles.

Topics & Concepts