Vaccination with Secreted Aspartyl Proteinase 2 Protein from<i>Candida parapsilosis</i>Can Enhance Survival of Mice during<i>C. tropicalis</i>-Mediated Systemic Candidiasis
Manisha Shukla, Soma Rohatgi
Abstract
The rising incidence of non-albicans Candida species globally, along with the emergence of drug resistance, is a cause for concern. This study investigated the protective efficacy of secreted aspartyl proteinase 2 (Sap2) in systemic C. tropicalis infection. Vaccination with recombinant Sap2 (rSap2) protein from C. parapsilosis enhanced survival of mice compared to rSap2 vaccinations from C. albicans ( P = 0.
Topics & Concepts
Systemic candidiasisBiologyCandida parapsilosisCandida albicansMicrobiologyVaccinationCorpus albicansCandida tropicalisImmunologyIncidence (geometry)OpticsPhysicsAntifungal resistance and susceptibilityPeptidase Inhibition and AnalysisFungal Infections and Studies