A tumor-targeted near-infrared fluorescent probe for HNO and its application to the real-time monitoring of HNO release <i>in vivo</i>
Ziyin Chai, Diankai Liu, Xiaoyi Li, Yanyan Zhao, Wen Shi, Xiaohua Li, Huimin Ma
Abstract
Nitroxyl (HNO) is a promising regulator for cancer therapy. Here, we develop a tumor-targeted near-infrared fluorescent probe for HNO and utilize it in the real-time imaging of HNO release in vivo.
Topics & Concepts
In vivoFluorescenceChemistryInfraredBiophysicsNanotechnologyBiomedical engineeringMaterials scienceBiologyOpticsMedicineBiotechnologyPhysicsNitric Oxide and Endothelin EffectsSulfur Compounds in BiologyNanoplatforms for cancer theranostics