Accelerator Production of Scandium Radioisotopes: Sc-43, Sc-44, and Sc-47
M. I. Chernysheva, Shaun Loveless, Tom Brossard, K. Becker, Shelbie J. Cingoranelli, Eduardo Aluicio‐Sarduy, J. Song, Paul A. Ellison, J. A. Nolen, David A. Rotsch, Suzanne E. Lapi, Jonathan W. Engle
Abstract
Scandium radioisotopes are increasingly considered viable radiolabels for targeted molecular imaging (Sc-43, Sc-44) and therapy (Sc-47). Significant technological advances have increased the quantity and quality of available radioscandium in the past decade, motivated in part by the chemical similarity of scandium to therapeutic radionuclides like Lu-177. The production and radiochemical isolation techniques applied to scandium radioisotopes are reviewed, focusing on charged particle and electron linac initiated reactions and using calcium and titanium as starting materials.