XPO1 inhibition synergizes with PARP1 inhibition in small cell lung cancer by targeting nuclear transport of FOXO3a
Jingya Wang, Tao Sun, Zhaoting Meng, Liuchun Wang, Mengjie Li, Jinliang Chen, Tingting Qin, Jiangyong Yu, Miao Zhang, Zhixin Bie, Zhiqiang Dong, Xiangli Jiang, Li Lin, Cuicui Zhang, Zhujun Liu, Richeng Jiang, Guang Yang, Lin Li, Yan Zhang, Dingzhi Huang
Topics & Concepts
PARP1PARP inhibitorCancer researchPoly ADP ribose polymeraseOlaparibBiologySynthetic lethalityApoptosisPharmacologyDNA repairPolymeraseDNABiochemistryPARP inhibition in cancer therapyFOXO transcription factor regulationDNA Repair Mechanisms