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Efficient estimation of pathwise differentiable target parameters with the undersmoothed highly adaptive lasso

Mark J. van der Laan, David Benkeser, Weixin Cai

2022The International Journal of Biostatistics20 citationsDOIOpen Access PDF

Abstract

Abstract We consider estimation of a functional parameter of a realistically modeled data distribution based on observing independent and identically distributed observations. The highly adaptive lasso estimator of the functional parameter is defined as the minimizer of the empirical risk over a class of cadlag functions with finite sectional variation norm, where the functional parameter is parametrized in terms of such a class of functions. In this article we establish that this HAL estimator yields an asymptotically efficient estimator of any smooth feature of the functional parameter under a global undersmoothing condition. It is formally shown that the L 1 -restriction in HAL does not obstruct it from solving the score equations along paths that do not enforce this condition. Therefore, from an asymptotic point of view, the only reason for undersmoothing is that the true target function might not be complex so that the HAL-fit leaves out key basis functions that are needed to span the desired efficient influence curve of the smooth target parameter. Nonetheless, in practice undersmoothing appears to be beneficial and a simple targeted method is proposed and practically verified to perform well. We demonstrate our general result HAL-estimator of a treatment-specific mean and of the integrated square density. We also present simulations for these two examples confirming the theory.

Topics & Concepts

EstimatorMathematicsDifferentiable functionApplied mathematicsIndependent and identically distributed random variablesEstimation theoryMathematical optimizationStatisticsMathematical analysisRandom variableStatistical Methods and InferenceAdvanced Causal Inference TechniquesStatistical Methods and Bayesian Inference
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