Nickel Catalyzed Cross-Coupling of Aryl and Alkenyl Triflates with Alkyl Thiols
Regina M. Oechsner, Ivo H. Lindenmaier, Ivana Fleischer
Abstract
We report a nickel catalyzed C-S cross-coupling of aryl and alkenyl triflates with alkyl thiols. A variety of the corresponding thioethers were synthesized using an air-stable nickel precatalyst under mild reaction conditions with short reaction times. A broad substrate scope, including pharmaceutically relevant compounds, could be demonstrated.
Topics & Concepts
ChemistryArylAlkylCatalysisNickelCoupling (piping)Organic chemistryCombinatorial chemistryPolymer chemistryMedicinal chemistryMetallurgyMaterials scienceSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsRadical Photochemical Reactions