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Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases

E. Weeks, Jacob C. Ulirsch, Nathan Cheng, Brian L. Trippe, Rebecca S. Fine, Jenkai Miao, Tejal A. Patwardhan, Masahiro Kanai, Joseph Nasser, Charles P. Fulco, Katherine Tashman, François Aguet, Taibo Li, José Ordovás-Montañés, Christopher S. Smillie, Moshe Biton, Alex K. Shalek, Ashwin N. Ananthakrishnan, Ramnik J. Xavier, Aviv Regev, Rajat M. Gupta, Kasper Lage, Kristin Ardlie, Joel N. Hirschhorn, Eric S. Lander, J Engreitz, Hilary K. Finucane

2023Nature Genetics304 citationsDOIOpen Access PDF

Topics & Concepts

BiologyGenome-wide association studyQuantitative trait locusComputational biologyPolygeneGeneGeneticsTraitGenomeGenetic associationSingle-nucleotide polymorphismComputer scienceGenotypeProgramming languageGenetic Associations and EpidemiologyRNA modifications and cancerBioinformatics and Genomic Networks
Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases | Litcius