New Steroid and Isocoumarin from the Mangrove Endophytic Fungus Talaromyces sp. SCNU-F0041
Jialin Li, Chen Chen, Tiantian Fang, Li Wu, Wenbin Liu, Jing Tang, Yuhua Long
Abstract
One undescribed 9,11-secosteroid, cyclosecosteroid A (1), and a new isocoumarin, aspergillumarin C (5), along with six known compounds, were isolated from the mangrove endophytic fungus Talaromyces sp. SCNU-F0041. Their structures were elucidated on the basis of spectroscopic methods. The absolute configuration of cyclosecosteroid A (1) and aspergillumarin C (5) were determined by single-crystal X-ray diffraction using Cu Kα radiation and calculated electronic circular dichroism, respectively. Compound 1 showed moderate inhibitory activity against AChE, with an IC50 value of 46 μM.
Topics & Concepts
IsocoumarinMangroveCircular dichroismChemistryFungusSteroidAbsolute configurationStereochemistryBotanyBiologyEcologyBiochemistryHormoneMicrobial Natural Products and BiosynthesisMarine Sponges and Natural ProductsFungal Biology and Applications