Msp1 cooperates with the proteasome for extraction of arrested mitochondrial import intermediates
Marion Basch, Mirjam Wagner, S. Rolland, Andres Carbonell, Rachel Zeng, Siavash Khosravi, Andreas Schmidt, Wasim Aftab, Axel Imhof, Johannes Wagener, Barbara Conradt, Nikola Wagener
Abstract
Msp1 homologue triggers an import stress response in the worm, which indicates a conserved role in metazoa. In summary, our results suggest a role of Msp1 as an adaptor for the proteasome that drives the extraction of arrested and mislocalized proteins at the mitochondrial outer membrane.
Topics & Concepts
BiologyProteasomeCell biologyBiogenesisMitochondrionMitochondrial biogenesisBiochemistryGeneMitochondrial Function and PathologyUbiquitin and proteasome pathwaysATP Synthase and ATPases Research