Copper(II)-Catalyzed Enantioselective Aza-Friedel–Crafts Reaction of Indoles with Isatin-Derived <i>N</i>-Boc-Ketimines
Leipeng Xue, Jiaqi Hou, Jiahui Li, Tianxu Yu, Qihang Cai, Shibo Yu, Chao Yao, Yue‐Ming Li
Abstract
The copper(II)-catalyzed enantioselective aza-Friedel–Crafts reaction of indoles with isatin-derived N -Boc-ketimines was developed by using tunable chiral O–N–N tridentate ligands derived from BINOL and proline. In general, the reaction afforded chiral 3-indolyl-3-aminooxindoles under mild conditions in high yields (83–97%) with excellent ee (69–99%).
Topics & Concepts
IsatinEnantioselective synthesisFriedel–Crafts reactionCatalysisChemistryCopperIndole testOrganic chemistryMedicinal chemistryCombinatorial chemistrySynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsAsymmetric Synthesis and Catalysis