Large-Area Interfaces for Single-Molecule Label-free Bioelectronic Detection
Eleonora Macchia, Fabrizio Torricelli, Paolo Bollella, Lucia Sarcina, Angelo Tricase, Cinzia Di Franco, Ronald Österbacka, Zsolt M. Kovács‐Vajna, Gaetano Scamarcio, Luisa Torsi
Abstract
However, it is a fact that a number of large-area transistors have been shown to detect at a limit of detection lower than femtomolar; they are also fast and hence innately suitable for point-of-care applications. This review critically discusses key elements, such as sensing materials, FET-structures, and target molecules that can be selectively assayed. The amplification effects enabling extremely sensitive large-area bioelectronic sensing are also addressed.
Topics & Concepts
ChemistryTransistorNanotechnologyMoleculeField-effect transistorSmall moleculeDetection limitInterface (matter)PhysicsMaterials scienceGibbs isothermBiochemistryQuantum mechanicsVoltageChromatographyOrganic chemistryNanowire Synthesis and ApplicationsAnalytical Chemistry and SensorsMolecular Junctions and Nanostructures