Concise synthesis of α-amino cyclic boronates via multicomponent coupling of salicylaldehydes, amines, and B2(OH)4

Wenbo Ming, Xiaocui Liu, Alexandra Friedrich, Johannes Krebs, Yudha P. Budiman, Mingming Huang, Todd B. Marder

2020Green Chemistry14 citationsDOI

Abstract

α-Amino cyclic boronates were synthesized from readily available salicylaldehydes, amines, and B2(OH)4. The process can be run at room temperature in ethanol, does not require catalysts or additives, and scale up and purification are easy.

Topics & Concepts

ChemistryCatalysisEthanolCoupling (piping)Process (computing)Scale (ratio)Organic chemistryCombinatorial chemistryMaterials scienceComputer sciencePhysicsMetallurgyQuantum mechanicsOperating systemOrganoboron and organosilicon chemistryCatalytic Cross-Coupling ReactionsChemical Synthesis and Analysis

Concise synthesis of α-amino cyclic boronates <i>via</i> multicomponent coupling of salicylaldehydes, amines, and B<sub>2</sub>(OH)<sub>4</sub>

Abstract

Topics & Concepts