Activation of Hippo signaling pathway mediates mitochondria dysfunction and dilated cardiomyopathy in mice
Wei Wu, Mark Ziemann, Kevin Huynh, Gang She, Zheng‐Da Pang, Yi Zhang, Thy Duong, Helen Kiriazis, Tian-Tian Pu, Ru‐Yue Bai, Jingjing Li, Yu Zhang, Mingxia Chen, Junichi Sadoshima, Xiu‐Ling Deng, Peter J. Meikle, Xiao‐Jun Du
Abstract
Hippo signaling activation mediates mitochondrial damage by repressing mitochondrial genes, which causally promotes the development of DCM. The Hippo pathway therefore represents a therapeutic target against mitochondrial dysfunction in cardiomyopathy.
Topics & Concepts
Hippo signaling pathwayMitochondrionCardiolipinBiologyCell biologyOxidative phosphorylationMitochondrial DNATranscription factorGeneSignal transductionBiochemistryMembranePhospholipidHippo pathway signaling and YAP/TAZRNA Research and Splicing