Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer’s disease
Qing Cao, Wei Wang, Jamal B. Williams, Fengwei Yang, Zijun Wang, Zhen Yan
Abstract
, which encodes serum and glucocorticoid-regulated kinase 1, is also significantly elevated in PFC of patients with AD. Administration of a specific Sgk1 inhibitor reduces hyperphosphorylated tau protein, restores PFC glutamatergic synaptic function, and ameliorates memory deficits in AD mice. These results have found a novel epigenetic mechanism and a potential therapeutic strategy for AD and related neurodegenerative disorders.
Topics & Concepts
H3K4me3GlutamatergicEpigeneticsNeurodegenerationNeuroscienceHistoneSGK1AMPA receptorBiologyAlzheimer's diseasePrefrontal cortexSynaptic plasticityMethyltransferaseMedicineCell biologyPhosphorylationDiseaseGlutamate receptorGeneInternal medicinePromoterCognitionGeneticsReceptorGene expressionMethylationEpigenetics and DNA MethylationAlzheimer's disease research and treatmentsNuclear Receptors and Signaling