Epigenetic repression of miR-17 contributed to di(2-ethylhexyl) phthalate-triggered insulin resistance by targeting Keap1-Nrf2/miR-200a axis in skeletal muscle
Jie Wei, Qiongyu Hao, Chengkun Chen, Juan Li, Xikui Han, Zhao Lei, Tao Wang, Yinan Wang, Xiang You, Xiaoxuan Chen, Huasheng Li, Yuxin Ding, Weihao Huang, Yangyang Hu, Shuirong Lin, Heqing Shen, Yi Lin
Abstract
The miR-17/Keap1-Nrf2/miR-200a axis contributed to DEHP-induced insulin resistance. miR-17 is a positive regulator, whereas miR-200a is a negative regulator of insulin signaling in skeletal muscle, and both miRNAs have the potential to become therapeutic targets for preventing and treating insulin resistance or type 2 diabetes.
Topics & Concepts
Insulin resistanceSkeletal musclePhthalateType 2 diabetesEpigeneticsInsulinEndocrinologyInternal medicineEndocrine systemDiabetes mellitusInsulin receptorMedicineBiologyChemistryGeneBiochemistryHormoneOrganic chemistryEffects and risks of endocrine disrupting chemicalsVitamin D Research StudiesDiet and metabolism studies