Fibronectin in development and wound healing
Jennifer Patten, Karin Wang
Abstract
Fibronectin structure and composition regulate contextual cell signaling. Recent advances have been made in understanding fibronectin and its role in tissue organization and repair. This review outlines fibronectin splice variants and their functions, evaluates potential therapeutic strategies targeting or utilizing fibronectin, and concludes by discussing potential future directions to modulate fibronectin function in development and wound healing.
Topics & Concepts
FibronectinWound healingCell biologyFunction (biology)FibronectinsSignal transductionBiologyNeuroscienceChemistryExtracellular matrixImmunologyCell Adhesion Molecules ResearchCellular Mechanics and InteractionsProtease and Inhibitor Mechanisms