Targeting the pyruvate dehydrogenase complex/pyruvate dehydrogenase kinase (PDC/PDK) axis to discover potent PDK inhibitors through structure-based virtual screening and pharmacological evaluation
Linling Gan, Ying Yang, Zizhen Liang, Maojie Zhang, Yun He, Shaolin Zhang, Shaolin Zhang
Topics & Concepts
Pyruvate dehydrogenase kinasePyruvate dehydrogenase complexChemistryPDK4GlycolysisVirtual screeningKinaseDrug discoveryIC50BiochemistryPyruvate dehydrogenase phosphataseOxoglutarate dehydrogenase complexLactate dehydrogenase APyruvate decarboxylationCell biologyEnzymeIn vitroBiologyCancer, Hypoxia, and MetabolismATP Synthase and ATPases ResearchEnzyme function and inhibition