Cu(<scp>i</scp>)- and Au(<scp>i</scp>)-catalyzed regioselective oxidation of diynes: divergent synthesis of N-heterocycles
Wen‐Bo Shen, Tingting Zhang, Meng Zhang, Jingjing Wu, Xiao‐Lei Jiang, Guang-Xin Ru, Guangqin Gao, Xiu-Hong Zhu
Abstract
The efficient and divergent construction of two types of valuable N-heterocycle is achieved easily, with the first example of the generation of α-oxo copper carbenes via copper-catalyzed oxidation of non-polarized alkynes.
Topics & Concepts
ChemistryRegioselectivityCatalysisCopperCombinatorial chemistryStereochemistryMedicinal chemistryOrganic chemistryCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms