A photocatalytic traceless C–N bond formation/cleavage strategy enabling the use of (α-chiral) alkyl aldehydes as deoxygenative (chiral) alkyl radical equivalents
Hanyang Bao, Limeng Zheng, Qian Liu, Mingfeng Han, Ya Li, Miao Bao, Yuanqiang Li, Pu‐Cha Yan, Yunkui Liu
Abstract
α-Chiral alkyl aldehydes were used as deoxygenative chiral alkyl radical equivalents for the first time in 4-CzIPN-catalyzed deoxygenative alkylation/cyclization of 2-biphenylisonitriles with alkyl aldehydes under photocatalytic conditions.
Topics & Concepts
ChemistryAlkylAlkylationPhotocatalysisBond cleavageCatalysisOrganic chemistryMedicinal chemistryPhotoredox catalysisRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques