Drug combinations targeting antibiotic resistance
Bence Bognár, Réka Spohn, Viktória Lázár
Abstract
While the rise of antibiotic resistance poses a global health challenge, the development of new antibiotics has slowed down over the past decades. This turned the attention of researchers towards the rational design of drug combination therapies to combat antibiotic resistance. In this review we discuss how drug combinations can exploit the deleterious pleiotropic effects of antibiotic resistance and conclude that each drug interaction has its prospective therapeutic application.
Topics & Concepts
AntibioticsDrugDrug resistanceMedicineAntibiotic resistancePharmacologyIntensive care medicineMicrobiologyBiologyAntibiotic Resistance in BacteriaAntibiotic Use and ResistanceAntibiotics Pharmacokinetics and Efficacy