In Vitro Confirmation of Artemisinin Resistance in <i>Plasmodium falciparum</i> from Patient Isolates, Southern Rwanda, 2019
Welmoed van Loon, R. N. Oliveira, Clara Bergmann, Felix Habarugira, Jules Ndoli, Augustin Sendegeya, Claude Bayingana, Frank P. Mockenhaupt
Abstract
A rtemisinin-based combination therapies (ACTs) have contributed greatly to the global decline of illness and death from malaria (1). However, the novel emergence of artemisinin resistance in eastern Africa has threatened the effectiveness of these breakthrough treatments (2-4). To avert potential disaster resulting from increased resistant malaria cases, the nature and extent of this resistance in Africa urgently needs to be characterized.
Topics & Concepts
ArtemisininPlasmodium falciparumMalariaVirologyBiologyDrug resistanceMicrobiologyIn vitroMutationMultiple drug resistanceGeneGeneticsImmunologyMalaria Research and ControlDrug-Induced Hepatotoxicity and ProtectionComputational Drug Discovery Methods