A novel polysaccharide from Acorus tatarinowii protects against LPS-induced neuroinflammation and neurotoxicity by inhibiting TLR4-mediated MyD88/NF-κB and PI3K/Akt signaling pathways
Jing Zhong, Xian Qiu, Qian Yu, Haiyun Chen, Chunyan Yan
Topics & Concepts
NeuroinflammationTLR4PI3K/AKT/mTOR pathwayProinflammatory cytokineProtein kinase BNeurotoxicityNeuroprotectionLY294002ChemistryPharmacologySignal transductionNF-κBLipopolysaccharideCell biologyInflammationBiochemistryBiologyImmunologyToxicityOrganic chemistryNeuroinflammation and Neurodegeneration MechanismsMedicinal Plants and NeuroprotectionIntensive Care Unit Cognitive Disorders