Nanocarrier-based gene delivery for immune cell engineering
Alireza Gharatape, Hamid Sadeghi Abandansari, Alexander M. Seifalian, Reza Faridi‐Majidi, Mohsen Basiri
Abstract
nanocarrier-based gene delivery can revolutionize cell-based cancer immunotherapies by replacing the current expensive autologous cell manufacturing with an off-the-shelf biomaterial-based platform. The aim of this research is to review current advances and strategies to overcome the challenges in nanoparticle-based gene delivery and their impact on the efficiency, safety, and specificity of the process. The main focus is on polymeric and lipid-based nanocarriers, and their recent preclinical applications for cancer immunotherapy.
Topics & Concepts
NanocarriersGene deliveryTransfectionImmunotherapyCancer immunotherapyGenetic enhancementImmune systemCancerComputational biologyCancer researchGeneMedicineBiologyImmunologyNanotechnologyDrug deliveryMaterials scienceGeneticsInternal medicineRNA Interference and Gene DeliveryGraphene and Nanomaterials ApplicationsAdvanced biosensing and bioanalysis techniques