Design, synthesis and molecular modeling studies of thiosemicarbazide & thiazolyl-hydrazone derivatives as potential anticancer agents and topoisomerase inhibitors

Sevil Şenkardeş, İrfan Bolat, Hazal Şahinbey, Sevgi Karakuş, Ömer Erdoğan, Pakize Cantürk, Serap Yılmaz Özgüven, Özge Çevik

2024Journal of Molecular Structure12 citationsDOI

Topics & Concepts

ChemistryTopoisomeraseHydrazoneCytotoxicityBenzamideStereochemistryEnzymeIC50Docking (animal)Cell cultureHydrazine (antidepressant)Topoisomerase inhibitorIn vitroBiochemistryGeneticsMedicineBiologyNursingCancer therapeutics and mechanismsSynthesis and biological activityBioactive Compounds and Antitumor Agents

Design, synthesis and molecular modeling studies of thiosemicarbazide &amp; thiazolyl-hydrazone derivatives as potential anticancer agents and topoisomerase inhibitors

Topics & Concepts

Design, synthesis and molecular modeling studies of thiosemicarbazide & thiazolyl-hydrazone derivatives as potential anticancer agents and topoisomerase inhibitors