Novel 1,3,5-triazine-based pyrazole derivatives as potential antitumor agents and EFGR kinase inhibitors: synthesis, cytotoxicity, DNA binding, molecular docking and DFT studies
M.S. Raghu, C.B. Pradeep Kumar, M.K. Prashanth, K. Yogesh Kumar, B.S. Prathibha, G. Kanthimathi, Siham A. Alissa, Hanan Al-Ghulikah, Sameh M. Osman
Abstract
The development of new 1,3,5-triazine-based pyrazole derivatives as effective anticancer agents.
Topics & Concepts
ChemistryPyrazoleCytotoxicityTriazineDocking (animal)Combinatorial chemistryDNAStereochemistryKinaseBiochemistryIn vitroOrganic chemistryMedicineNursingSynthesis and Characterization of Heterocyclic CompoundsClick Chemistry and ApplicationsSynthesis and biological activity