GENOME-WIDE ANALYSIS OF TRIPLE-NEGATIVE PHENOTYPE BREAST TUMORS
М.K. Ibragimova, M.M. Tsyganov, N.V. Litvyakov
Abstract
Identification of the molecular genetic phenotype of breast carcinomas is an important prognostic factor of the disease, and helps to personalize the treatment of such patients. According to the evidence data from the reference literature, breast cancer (BC) with a triple negative phenotype among all molecular subtypes accounts for about 10-24%, showing the most aggressive progression and, as a result, has the worst prognosis.
Topics & Concepts
PhenotypeTriple-negative breast cancerBreast cancerTriple negativeDiseaseIdentification (biology)OncologyBiologyMedicineCancerInternal medicineGeneGeneticsBotanyBioinformatics and Genomic NetworksGenetics, Bioinformatics, and Biomedical ResearchBRCA gene mutations in cancer