Sulfur-Directed C<sub>7</sub>-Selective Alkenylation of Indoles under Rhodium Catalysis
Chandrababu Naidu Kona, Yuji Nishii, Masahiro Miura
Abstract
Regioselective direct functionalization of an indole benzenoid fragment has been a significant challenge because of its inherently lower reactivity. In this report, we introduce a Rh-catalyzed C7-selective alkenylation of indole derivatives using a new sulfur directing group N-SCy. A notable feature of this system is that the directing group is readily installed to the indoles and easily removed after the catalysis under mild conditions.
Topics & Concepts
RegioselectivityIndole testChemistryRhodiumReactivity (psychology)CatalysisSulfurCombinatorial chemistrySurface modificationFunctional groupGroup (periodic table)Organic chemistryAlternative medicineMedicinePhysical chemistryPathologyPolymerCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesCyclopropane Reaction Mechanisms